Acid-related diseases of the gastrointestinal system affect an estimated 29% of Canadian adults. PPIs are commonly used for the treatment of acid-related disorders such as gastroesophageal reflux disease, reflux esophagitis and peptic ulcer disease.
In 2007, Canadians spent an estimated $1.4 billion on prescription acid-reducing drugs, with about half of this total spent by seniors. It is estimated that roughly 90% of prescription expenditures on acid-reducing drugs are for PPIs. While PPIs are generally considered to be safe medications, concerns have emerged regarding the effect of long-term and high-dose PPI use on people's health.
This analysis of NPDUIS Database data from Alberta, Saskatchewan, Manitoba, New Brunswick, Nova Scotia and P.E.I. examines trends in the use of PPIs in seniors between 2001-2002 and 2007-2008.
The age–sex standardized rate of PPI use among seniors on public drug programs increased from 13.1% in 2001-2002, to 21.1% in 2007-2008. In the same time period, total drug program expenditures for PPIs increased from $41.8 million to $69.8 million, accounting for 7.3% of total drug program expenditures.
The chronic use of PPIs (three claims for a PPI in a given year and with at least 180 days' supply) increased from 53.9% of seniors with PPI claims in 2001-2002, to 65.4% of seniors with PPI claims in 2007-2008. PPI use among chronic users of non-steroidal anti-inflammatory drugs (NSAIDs) increased from 17.4% in 2001-2002, to 30.2% in 2007-2008.
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